Artificial Hippocampus? Immortality? Plausible?

MythBusting time!

I am definitely expecting a classmate to blog about this also. Did anyone catch Curioity: Can You Live Forever with Adam Savage the other night? Pretty cool as far as speculative science goes, right? My answer to that is yes. Now, can we make the MythBuster immortal? Maybe we can, but there is one part of this that aroused my desire to go MythBusting.

The hypothetical future Adam says at one point that at 500 years, the hippocampus, a large mass in the brain involved in memory, ran out of space. His solution: Build an artificial hippocampus. Also, multiple bodies. Way far out, right?

Wait! Let’s put the Kurzweil-esque thinking aside. What was this about the hippocampus (which literally means “seahorse”)? I remember hearing in psychology courses that the hippocampus was involved in memory, but that it probably was not the location of memory storage.

Myth: (1) The Hippocampus is the brain’s natural storage center, and (2) it is possible to increase memory storage capacity by making an artificial extension of the brain.

Let’s first take a look at this myth via Wikipedia.

Role in memory

See also: Amnesia

Psychologists and neuroscientists generally agree that the hippocampus has an important role in the formation of new memories about experienced events (episodic or autobiographical memory).[16][20] Part of this role is hippocampal involvement in the detection of novel events, places and stimuli.[21] Some researchers view the hippocampus as part of a larger medial temporal lobe memory system responsible for general declarative memory (memories that can be explicitly verbalized—these would include, for example, memory forfacts in addition to episodic memory).[15]

Due to bilateral symmetry the brain has a hippocampus in both cerebral hemispheres, so every normal brain has two of them. If damage to the hippocampus occurs in only one hemisphere, leaving the structure intact in the other hemisphere, the brain can retain near-normal memory functioning.[22] Severe damage to the hippocampus in both hemispheres results in profound difficulties in forming new memories (anterograde amnesia), and often also affects memories formed before the damage (retrograde amnesia). Although the retrograde effect normally extends some years before the brain damage, in some cases older memories remain—this sparing of older memories leads to the idea that consolidation over time involves the transfer of memories out of the hippocampus to other parts of the brain.

Interesting. So far, it seems that the hippocampus is more of an encoding structure. But, a good MythBuster does not stop at Wikipedia. So let’s look at some recent primary research!

In 2009, Leonardo Restivo and colleagues wanted to see what structural changes happened in the hippocampus and anterior cingulate cortex. What they did was condition contextual fear in mice, except that they also had a control group of non-conditioned or pseudoconditioned mice. Next, they tested some of the mice 24 hours later (recent memory recall), tested some mice 36 days later (remote memory recall), and left some mice untested (another control measure). After this, they put the mice to sleep, cut out their brains and put the brains in a Golgi-Cox staining solution to look at neural growth.

Now that the scientists had these beautifully stained mouse brains, it was time to look at the structure. They made slides and checked for dendritic spine growth, a sign of neural plasticity. What they found was that in mice tested for recent memory recall there was more structural change going on in the CA1 region of the hippocampus, but in mice tested for remote memory, there was a high dendritic spine density in the anterior cingulate cortex (aCC) (Restivo et al., 2009, Fig 2).

In both recent and remote tested mice, as well as untested, there was a higher density of dendritic spines than in pseudoconditioned and naive mice. (Plasticity in behaviorally untested mice means that this stuff is going on without needing recall.) Pseudoconditioned mice also had higher spine density than naive mice.

They also tested what would happen when they formed hippocampal lesions. It turned out that lesions formed soon after conditioning hindered recall, and when slides were made of the brain, but significantly more spines were seen than in control mice on dendrites of aCC cells. However, when lesions were caused later (day 24) recall was not as severely hindered, and more spines were seen on aCC pyramidal cells than in the mice who had early lesions. (Restivo et al., 2009, Fig 5).

What does this all mean? Well, it suggests that the hippocampus has an important but limited role in memory formation and storage. We can see things going on (spines being formed) in the hippocampus when memory is being formed, and those spines are still somewhat present in tests for remote memory. However, when testing later after conditioning, more new connections are seen in the anterior cingulate cortex. We also have the evidence from lesions, showing that damage to the hippocampus does not much of an effect on remote memory. Therefore, we can probably conclude that the hippocampus is not a storage center, but rather a memory processing center.

Myth: “Hippocampus specifically a Memory Storage Center”: This part is BUSTED.

Myth: “Creating an External Hard Drive for your Brain”: This part is PLAUSIBLE and is also a whole other subject.

Cited

Restivo L, Vetere G, Bontempi B, Ammassari-Teule M. The formation of recent and remote memory is associated with time-dependent formation of dendritic spines in the hippocampus and anterior cingulate cortex. J. Neurosci. 29(25): 8206-8214.

Also thanks to wikipedia, youtube and Discovery: Curiosity.

5 Comments

  1. […] Immortality. […]

  2. […] Immortality. […]

  3. I hope you carry on updating the blog after the semester ends, appreciate there will be many distractions, but I enjoyed reading this and I got the impression you quite enjoyed writing it. Would like to see what else interests you.

  4. That’s some excellent detective work – that distinction you make between recent and remote memory is a crucial one. It’s nice to hear a voice of reason amid all the pop pseudoscience of the “structure = function” school (if that even counts as a “school” at all).

  5. Artificial extension of brain/memory capacity? We’ve had that for thousands of years. They’re called books, and have fairly standard interfaces (serial-inteface = scrolls, index-sequential = numbered pages). Nowadays we have the Wikipedia interface (ISAM vis B*-trees). So we’re still waiting for the direct interface (USB3.0 to the spinal chord?) of science fiction.


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